CAS NO. 67-97-0 Liposomal Vitamin D3

Vitamin D3 is a fat-soluble molecule and is mainly bound in the following ways:

Embedded in lipid bilayer: The hydrophobic properties of vitamin D3 allow it to be stably embedded in the hydrophobic area of the phospholipid bilayer.

Protective wrapping: The liposome bilayer membrane isolates oxygen, light and enzymatic hydrolysis, reducing the degradation of vitamin D3.

2.1 High bioavailability

Membrane-like structure promotes absorption: Liposomes are similar to intestinal cell membranes and directly enter the circulatory system through membrane fusion or endocytosis, bypassing the loss of traditional digestive processes.

Lymphatic system absorption: Liposomes can be absorbed through intestinal lymph (chylomicron pathway), improving the transport efficiency of fat-soluble vitamin D3.

Figure 1:  It has been demonstrated in a clinical experiment that liposomes Vitamin D3 are superior to oily formulation concerning their capability in delivering vitamin D3. Also, the clinical experiment shows that vitamin D3 in liposomal form was absorbed faster by persons with distinct deficiency.

3.1 Protective effect of the bilayer membrane: Reduce photooxidation and hydrolysis of vitamin D3 (especially in gastric acid environment).

3.2 Regulatory effect of cholesterol: Reduce the fluidity of phospholipid molecules, prevent liposome rupture and leakage of active ingredients.

4.1 Passive targeting: Liposomes can be enriched in specific tissues through the EPR effect (such as nano-liposomes).

4.2 Sustained release characteristics: The phospholipid bilayer gradually releases vitamin D3 to maintain stable blood drug concentration.

its activity.

Hydrophilic shell: The hydrophilic layer on the surface of liposomes allows fat-soluble vitamin D3 to be evenly dispersed in aqueous media (such as beverages, oral liquids), expanding application scenarios.