Beyond Standard Milk Thistle: How LiposoMore® Liposomal Silymarin Delivers 92% Bioavailability and Superior Liver Protection

In the competitive global nutrition market, the effectiveness of a liver support supplement is dictated by one factor: bioavailability. Silymarin, the active antioxidant complex found in milk thistle (Silybum marianum), has been a staple for liver health for decades. However, traditional silymarin formulations face a significant "bioavailability bottleneck" due to their poor water solubility and low absorption rates.

At LiposoMore®, a premium brand under Joyful Nutritional Supply Co., ltd., we have leveraged over 20 years of expertise to solve this challenge. By utilizing advanced liposomal encapsulation technology, we provide a high-efficiency solution that ensures nutrients reach their target cells.

The Bioavailability Bottleneck of Traditional Milk Thistle

Silymarin is highly lipophilic and virtually insoluble in water. When consumed in standard powder or capsule form, the human body typically absorbs only 20% to 50% of the active compound. Furthermore, traditional silymarin is highly susceptible to metabolic transformation and degradation by stomach acid before it can ever reach the liver.

LiposoMore® Technology: Engineered for Superior Nutrient Delivery

LiposoMore® Liposomal Silymarin is precision-engineered to bypass these digestive barriers. Our technology coats silymarin with a phospholipid bilayer—a structure that mimics human cell membranes.

Core Technological Advantages

• Gastric Acid Resistance: The phospholipid bilayer effectively protects the silymarin from the harsh acidic environment of the stomach.

• Targeted Delivery Mechanism: Direct delivery to target cells via the lymphatic system, avoiding first-pass metabolism.

• Intelligent Sustained-Release: This technology extends the time the nutrient remains active in the bloodstream.

• Gentle Formulation: The encapsulation minimizes the gastrointestinal irritation often associated with high-dose herbal extracts.

Scientific Proof: 4.8x Higher Absorption and Enhanced Efficacy

Clinical data confirms that LiposoMore® technology drastically outperforms traditional formulations. In pharmacokinetic trials comparing our Liposomal Silymarin (L-SIL) to Standard Silymarin (T-SIL), L-SIL demonstrated a revolutionary leap in utilization.

Pharmacokinetic Data Comparison

The results show that LiposoMore® achieves a peak concentration approximately 4.8 times higher than traditional extracts, with a total relative bioavailability of 92%.

Clinical Evidence: Significant Reduction in Serum ALT and AST Levels

To evaluate biological efficacy, researchers utilized a mouse model of immune-mediated liver injury (induced by BCG + LPS). Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) are critical biomarkers; when liver cells are damaged, these enzymes leak into the bloodstream in large quantities.

Serum ALT Level Changes (U/L)

Establishment of Animal Model：

The mouse model of immune-mediated liver injury was established using a combined BCG + LPS induction method, based on the dual-activation mechanism of the immune system. Initially, BCG acts as an antigen to sensitize T lymphocytes and macrophages, triggering primary inflammatory cytokine release and granulomatous infiltration. Subsequently, LPS is administered as a secondary challenge to further activate these sensitized immune cells, leading to a massive surge of pro-inflammatory cytokines. This "cytokine storm" induces oxidative stress, lipid peroxidation, and necrosis in hepatocytes. The successful establishment of the model is confirmed by significantly elevated serum ALT and AST levels, alongside focal hepatocyte degeneration and necrosis in liver tissues.

Results: Elevated serum ALT levels in the model group confirmed the successful establishment of the liver injury model. Compared with the model group, serum ALT levels were significantly reduced in the medium/high-dose T-SIL groups and all L-SIL groups. Notably, at low and medium doses, L-SIL demonstrated superior efficacy to T-SIL in lowering ALT levels.

Figure 1 Serum ALT levels

The summary sheet for ALT Level:

Figure 2 Serum AST levels

The summary sheet for AST Level:

Serum AST levels were significantly reduced in the high-dose T-SIL group and all dose groups of L-SIL. In the low- and medium-dose groups, the effect of L-SIL was significantly higher than that of T-SIL.

The study demonstrated that LiposoMore® Liposomal silymarin L-SIL was significantly more effective at restoring healthy enzyme levels than traditional forms.

Key Insight: Notably, the low dose of LiposoMore® L-SIL (46.9 U/L) provided liver protection nearly equivalent to the high dose of traditional silymarin (41.8 U/L), proving that LiposoMore® offers deeper protection for liver tissue.

Case Study: Success in the Utah Dietary Supplement Market

The Client: A premier dietary supplement brand based in Utah, USA, focused on high-end metabolic and detox formulations.

The Challenge: The client’s existing liver detox product used a standard 80% silymarin extract. Despite quality sourcing, customers reported minimal "felt effect," and the brand struggled to differentiate itself in the crowded US market.

The Solution: The brand partnered with the LiposoMore® ODM Center to reformulate their liver support capsule. We provided a customized Liposomal Silymarin Powder with a 33.5% silymarin assay, validated as "True Liposomal" via TEM and particle size analysis.

The Result:

• Formulation Stability: Our powder achieved a ≥90% encapsulation rate, ensuring stability during the encapsulation process.

• Market Differentiation: The client marketed the product as a "Cellular-Targeted Delivery System," backed by our clinical bioavailability data.

• Commercial Growth: Within six months, the reformulated capsule became their best-selling detox product, seeing a 40% rise in repeat customer purchases due to its superior efficacy in supporting healthy liver enzyme ranges.

Partner with LiposoMore® for High-Efficiency Nutrition

As a science-driven leader, LiposoMore® ensures that every batch of our ingredients—from vitamins to minerals and specialty nutrients like silymarin—conforms to international GMP, ISO 22000, and HACCP standards.

We provide our global partners with full technical documentation (COA, TEM, DLS) and formulation support to help your brand stand out with superior performance.

Revolutionize your liver health category with LiposoMore® Liposomal Silymarin.

Natalie Wu

Hey Guys, I am Natalie Wu, an R&D researcher at LiposoMore. I graduate from College with a Master’s Degree in Bioengineering, I would like to share news and the science behind liposomal ingredients. At LiposoMore, we drive ingredient development with scientific precision and a passion for advanced nutritional technologies.